Bioresorbable polymeric envelope that stabilizes the implanted pacemaker reducing the risk of CIED infections
Infections related to the implantation of cardiovascular implantable electronic devices or CIEDs occur at high frequency (up to ca. 20% of the interventions) and are associated with a 2-fold increase in mortality rate. A solution that delivers a potent anti-infective locally that can eradicate resistant bacterial strains, fungal species, and is efficacious against biofilms is currently missing.
N8 Medical is developing a bioresorbable polymeric envelope, that stabilizes the implanted pacemaker and eliminates a broad spectrum of pathogens (including resistant bacteria and fungi) causing CIED infections, through the application of ceragenins, a novel class of anti-infectives designed to mimic naturally occurring antimicrobial peptides.